Ontology of Drug Adverse Events

Last uploaded: January 12, 2019
Preferred Name

endocrine system

Synonyms

systema endocrinum

endocrine system

endocrine glandular system

Definitions

Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.

ID

http://purl.obolibrary.org/obo/UBERON_0000949

composed primarily of

http://purl.obolibrary.org/obo/UBERON_0002368

database_cross_reference

http://linkedlifedata.com/resource/umls/id/C0014136

http://en.wikipedia.org/wiki/Endocrine_system

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12705

http://www.snomedbrowser.com/Codes/Details/278876000

MESH:D004703

FMA:9668

EHDAA2:0002224

MA:0000012

ZFA:0001158

GAID:439

AAO:0010279

EMAPA:35306

TAO:0001158

XAO:0000158

FBbt:00005068

UMLS:C0014136

CALOHA:TS-1301

VHOG:0000098

EV:0100128

EFO:0002969

definition

Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.

existence ends during

http://purl.obolibrary.org/obo/UBERON_0000066

external_definition

Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]

has exact synonym

systema endocrinum

endocrine system

endocrine glandular system

has_obo_namespace

uberon

has_relational_adjective

endocrine

homology_notes

Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]

id

UBERON:0000949

imported from

http://purl.obolibrary.org/obo/oae.owl

http://purl.obolibrary.org/obo/uberon.owl

in_subset

http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim

http://purl.oboInOwllibrary.org/oboInOwl/uberon#vertebrate_core

http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim

http://purl.oboInOwllibrary.org/oboInOwl/uberon#uberon_slim

http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim

http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core

label

endocrine system

notation

UBERON:0000949

prefLabel

endocrine system

subClassOf

http://purl.obolibrary.org/obo/UBERON_0000467

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/UBERON_0000949 PATO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 UBERON SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 OBA SAME_URI
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http://purl.obolibrary.org/obo/UBERON_0000949 OAE SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 RBO SAME_URI
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http://purl.obolibrary.org/obo/UBERON_0000949 OHPI SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 FOVT SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 OCMR SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 HOIP SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 DOID SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 XPO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 HSO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 PCL SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 PATO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 NIFDYS SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 BERO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 NBO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 HHEAR SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 TXPO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 GSSO SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 OBA SAME_URI
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http://purl.obolibrary.org/obo/UBERON_0000949 AISM SAME_URI
http://purl.obolibrary.org/obo/UBERON_0000949 NMDCO SAME_URI
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http://who.int/bodysystem.owl#EndocrineSystem ICD11-BODYSYSTEM LOOM
http://purl.obolibrary.org/obo/FBbt_00005068 FB-BT LOOM
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http://purl.obolibrary.org/obo/TAO_0001158 TAO LOOM
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http://www.projecthalo.com/aura#Endocrine-System AURA LOOM
http://purl.jp/bio/4/id/200906055758638770 IOBC LOOM
http://purl.obolibrary.org/obo/CLAO_0001125 CLAO LOOM
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http://purl.bioontology.org/ontology/MESH/D004703 MESH LOOM
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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Endocrine_System SYN LOOM
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http://purl.obolibrary.org/obo/UBERON_0000949 RBO LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 CLO LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 OHPI LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 FOVT LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 OCMR LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 HOIP LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 DOID LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 XPO LOOM
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http://purl.obolibrary.org/obo/UBERON_0000949 PCL LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 PATO LOOM
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http://purl.obolibrary.org/obo/UBERON_0000949 GSSO LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 OBA LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 UPHENO LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 OCVDAE LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 NIFSTD LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 KTAO LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 MAXO LOOM
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http://purl.obolibrary.org/obo/UBERON_0000949 FNS-H LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 AISM LOOM
http://purl.obolibrary.org/obo/UBERON_0000949 NMDCO LOOM
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http://sig.uw.edu/fma#Endocrine_system HUPSON LOOM
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http://purl.obolibrary.org/obo/EMAPA_35306 EMAPA LOOM
http://www.icn.ch/icnp#EndocrineSystem ICNP LOOM
http://purl.obolibrary.org/obo/OMIT_0005946 OMIT LOOM