Ontology of Drug Adverse Events

Last uploaded: January 12, 2019
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Preferred Name

Teniposide [Chemical/Ingredient]
Synonyms
ID

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000006147
code

C22638
Display_Name

Teniposide
imported from

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl
label

Teniposide [Chemical/Ingredient]
MeSH_CUI

M0021161
MeSH_Definition

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
MeSH_DUI

D013713
MeSH_Name

Teniposide
NUI

N0000006147
prefixIRI

NDF-RT:N0000006147
prefLabel

Teniposide [Chemical/Ingredient]
RxNorm_CUI

10362
RxNorm_Name

Teniposide
Synonym

Demethyl Epipodophyllotoxin Thenylidine Glucoside

Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
UMLS_CUI

C0039512
subClassOf

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007634
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