Ontology of Drug Adverse Events

Last uploaded: January 12, 2019

Preferred Name	Simvastatin [Chemical/Ingredient]
Synonyms
ID	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842
code	C22028
Display_Name	Simvastatin
imported from	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl
label	Simvastatin [Chemical/Ingredient]
MeSH_CUI	M0029425
MeSH_Definition	A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
MeSH_DUI	D019821
MeSH_Name	Simvastatin
NUI	N0000005842
prefixIRI	NDF-RT:N0000005842
prefLabel	Simvastatin [Chemical/Ingredient]
RxNorm_CUI	36567
RxNorm_Name	Simvastatin
Synonym	Synvinolin
UMLS_CUI	C0074554
subClassOf	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106

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Mapping To	Ontology	Source
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	INBANCIDO	SAME_URI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	CIDO	SAME_URI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	OCVDAE	SAME_URI
http://purl.bioontology.org/ontology/NDFRT/N0000005842	NDFRT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	CIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000005842	OCVDAE	LOOM