Ontology for Biomedical Investigations

Last uploaded: May 19, 2026
Id http://purl.obolibrary.org/obo/OBI_0000377
http://purl.obolibrary.org/obo/OBI_0000377
Preferred Name

perturb function
Definitions
A perturb function is a function that disrupts the normal function of a system induced through either internal or external means. External means of perturbation include: (1) displacement fields in the physical sense - e.g., temperature change, osmotic shock, pressure change; (2) application of small molecules such as drugs or toxins to perturb the function of specific pathways or application of surfactants to perturb the normal function of plasma membrane. Internal means of perturbation include: (1) manipulation of gene function via gene knockout or transcript knockdown via RNAi; (2) directed genetic mutation leading to minimal aa alterations that interfere with peptide function.
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
perturb function
perturb function
label
perturb function
textual definition
A perturb function is a function that disrupts the normal function of a system induced through either internal or external means. External means of perturbation include: (1) displacement fields in the physical sense - e.g., temperature change, osmotic shock, pressure change; (2) application of small molecules such as drugs or toxins to perturb the function of specific pathways or application of surfactants to perturb the normal function of plasma membrane. Internal means of perturbation include: (1) manipulation of gene function via gene knockout or transcript knockdown via RNAi; (2) directed genetic mutation leading to minimal aa alterations that interfere with peptide function.
type
has curation status
definition source
prefixIRI
OBI:0000377
editor preferred term
perturb function
term editor
Melanie Courtot
Daniel Schober
Frank Gibson
Bill Bug
subClassOf
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