Preferred Name |
submandibular gland |
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Synonyms |
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Definitions |
lobular, sexually dimorphic in mouse |
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ID |
http://purl.obolibrary.org/obo/UBERON_0001736 |
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comment |
lobular, sexually dimorphic in mouse |
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BSPO_0000126 | ||
depiction |
http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg |
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develops_from | ||
label |
submandibular gland |
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only in taxon | ||
part_of | ||
prefixIRI |
UBERON:0001736 |
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prefLabel |
submandibular gland |
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treeView | ||
UBPROP_0000008 |
In humans, they account for 70% of the salivary volume and weigh about 15 grams. [WP,unvetted] in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty[MGI:anna] |
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UBPROP_0000011 |
The submandibular is the first major salivary gland to develop in the embryo, followed by the neighbouring sublingual and then the parotid.[PMID:17336109] |
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UBPROP_0000013 |
The term submandibular as used in humans, is incorrect due the difference in topography of these structures[http://www.avdc.org] |
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subClassOf |