<ncicp:ComplexDefinition><ncicp:def-definition>Tubulin binding agent that binds to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. Interfering with microtubule dynamics, these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis. [source: NCIT]</ncicp:def-definition></ncicp:ComplexDefinition>

http://purl.bioontology.org/ontology/npo#NPO_556

NPO_556

NCIT:C67437

<ncicp:ComplexDefinition><ncicp:def-definition>Tubulin binding agent that binds to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. Interfering with microtubule dynamics, these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis. [source: NCIT]</ncicp:def-definition></ncicp:ComplexDefinition>

taxane-pocket binding agent

taxane-pocket binding agent

npo:NPO_556

taxane-pocket binding agent

http://purl.bioontology.org/ontology/npo#NPO_315