Preferred Name

dextromethorphan

Synonyms

Robitussin Maximum Strength

Calmylin #1

Koffex DM

Tusilan

Hihustan M

L-Methorphan

Medicon

Demorphan Hydrobromide

Antussan

Delsym Cough Formula

Sucrets 4 Hour Cough

Levometorfano (INN-Spanish)

Strength

Metrorat

D-Methorphan Hydrobromide

Vicks 44 Cough Relief

Novahistex DM

Levomethorphan (Ban:Dcf:Inn)

Demorphan

d-Methorphan

Dextrometorfano (INN-Spanish)

DXM

Demorphine

Benylin DM 12 Hour

Levomethorphan

Delta-Methorphan

Benylin Pediatric Cough

Cosylan

Creo-Terpin

Bromhydrate

Benylin Adult Formula Cough

Trocal

Dexyromethorphan

Canfodion

Dextromethorfan (Czech)

Benylin DM for Children 12

Suppressant

Dormethan

Pertussin CS Children's

Balminil DM

3-methoxy-17-methylmorphinan

Novahistine DM

Levomethorphanum (INN-Latin)

Hour

Dextrometorphan

Destrometerfano (Dcit)

Delsym

Tussade

delta-Methorphan

Pertussin DM Extra Strength

Balminil DM Children

Cough Suppressant

Romilar

Benylin DM for Children

Diabe-Tuss DM Syrup

Dextromorphan

D-Methorphan

Benylin DM

Dextromethorphan Bromide

Methorphan

Robitussin Pediatric

Dextromethorphan

Levomethorphane (INN-French)

Dormetan

Methorate Hydrobromide

Robitussin Pediatric Cough

Triaminic DM Long Lasting for Children

Definitions

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough. Street names: Cough-X, Hold DM

ID

http://purl.obolibrary.org/obo/CHEBI_4470

comment

Street names: Cough-X, Hold DM

bearer of

http://uri.neuinfo.org/nif/nifstd/nlx_chem_090801

charge

0

createdDate

March 5, 2010

database_cross_reference

PMID:18198471

CAS:125-71-3

HMDB:HMDB0001920

Reaxys:88549

Wikipedia:Dextromethorphan

PMID:17461892

KEGG:D03742

DrugBank:DB00514

KEGG:C06947

PMID:24269965

definition

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists

formula

C18H25NO

has role

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_50910

http://purl.obolibrary.org/obo/CHEBI_51177

http://purl.obolibrary.org/obo/CHEBI_78298

http://purl.obolibrary.org/obo/CHEBI_60643

has_exact_synonym

3-methoxy-17-methylmorphinan

Dextromethorphan

has_obo_namespace

chebi_ontology

has_related_synonym

d-Methorphan

DXM

delta-Methorphan

hasExternalSource

DB00514

hasStreetName

Hold DM

Cough-X

id

CHEBI:4470

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1

inchikey

MKXZASYAUGDDCJ-CGTJXYLNSA-N

label

dextromethorphan

mass

271.39724

modifiedDate

June 30, 2010

monoisotopicmass

271.19361

notation

CHEBI:4470

prefLabel

dextromethorphan

smiles

[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2Cc2ccc(OC)cc12

synonym

Robitussin Maximum Strength

Calmylin #1

Koffex DM

Tusilan

Hihustan M

L-Methorphan

Medicon

Demorphan Hydrobromide

Antussan

Delsym Cough Formula

Sucrets 4 Hour Cough

Levometorfano (INN-Spanish)

Strength

Metrorat

D-Methorphan Hydrobromide

Vicks 44 Cough Relief

Novahistex DM

Levomethorphan (Ban:Dcf:Inn)

Demorphan

Dextrometorfano (INN-Spanish)

Demorphine

Benylin DM 12 Hour

Levomethorphan

Delta-Methorphan

Benylin Pediatric Cough

Cosylan

Creo-Terpin

Bromhydrate

Benylin Adult Formula Cough

Trocal

Dexyromethorphan

Canfodion

Dextromethorfan (Czech)

Benylin DM for Children 12

Suppressant

Dormethan

Pertussin CS Children's

Balminil DM

Novahistine DM

Levomethorphanum (INN-Latin)

Hour

Dextrometorphan

Destrometerfano (Dcit)

Delsym

Tussade

Pertussin DM Extra Strength

Balminil DM Children

Cough Suppressant

Romilar

Benylin DM for Children

Diabe-Tuss DM Syrup

Dextromorphan

D-Methorphan

Benylin DM

Dextromethorphan Bromide

Methorphan

Robitussin Pediatric

Levomethorphane (INN-French)

Dormetan

Methorate Hydrobromide

Robitussin Pediatric Cough

Triaminic DM Long Lasting for Children

textual definition

An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_35618

http://purl.obolibrary.org/obo/CHEBI_38163

http://uri.neuinfo.org/nif/nifstd/nlx_chem_1003011

http://purl.obolibrary.org/obo/CHEBI_25418

http://purl.obolibrary.org/obo/CHEBI_83818

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