Neuroscience Information Framework (NIF) Standard Ontology

Last uploaded: February 10, 2018

Id	http://uri.neuinfo.org/nif/nifstd/birnlex_12566 http://uri.neuinfo.org/nif/nifstd/birnlex_12566
Preferred Name	Amyotrophic Lateral Sclerosis
Definitions	A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH).
Synonyms	Gehrigs Disease Lou Gehrig Disease Lou Gehrig's Disease Gehrig's Disease Lou Gehrigs Disease
Type	http://www.w3.org/2002/07/owl#Class

definition	A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH).
alternative label	Gehrigs Disease Lou Gehrig Disease Lou Gehrig's Disease Gehrig's Disease Lou Gehrigs Disease
preferred label	Amyotrophic Lateral Sclerosis
label	Amyotrophic Lateral Sclerosis
externalSourceId	D000690 _8.3_2.5.1
synonym	Gehrigs Disease Lou Gehrig Disease Lou Gehrig's Disease Gehrig's Disease Lou Gehrigs Disease
acronym	ALS
hasExternalSource	http://uri.neuinfo.org/nif/nifstd/readable/MeSH
createdDate	October 5, 2007
note	A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). http://uri.neuinfo.org/nif/nifstd/readable/uncurated
definingCitationURI	http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/amyotrophiclateralsclerosis.htm
hasCurationStatus	http://uri.neuinfo.org/nif/nifstd/readable/uncurated
MeshUid	D000690
subClassOf	http://uri.neuinfo.org/nif/nifstd/birnlex_12565 http://purl.obolibrary.org/obo/DOID_231
hasDefinitionSource	http://uri.neuinfo.org/nif/nifstd/readable/MeSH_defSource
Resource Identifier	D000690 _8.3_2.5.1
hasBirnlexCurator	http://uri.neuinfo.org/nif/nifstd/readable/Bill_Bug
editorial note	http://uri.neuinfo.org/nif/nifstd/readable/uncurated
type	http://www.w3.org/2002/07/owl#Class
modifiedDate	April 11, 2009
nifID	_8.3_2.5.1
definingCitation	Adams et al., Principles of Neurology, 6th ed, pp1089-94

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