loading...| Preferred Name |
tumor necrosis factor alpha |
|
| Synonyms |
TNFA TNFSF2 TNF TNF-a TNF-alpha tumor necrosis factor ligand superfamily member 2 cachectin |
|
| Definitions |
A tumor necrosis factor, TNF-like that is a translation product of the TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. Category=gene. |
|
| ID |
http://purl.obolibrary.org/obo/PR_000000134 |
|
| comment |
Category=gene. |
|
| alternative label |
TNFA TNFSF2 TNF TNF-a TNF-alpha tumor necrosis factor ligand superfamily member 2 cachectin |
|
| database_cross_reference |
PIRSF:PIRSF500467 |
|
| definition |
A tumor necrosis factor, TNF-like that is a translation product of the TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. Category=gene. |
|
| equivalentClass | ||
| has exact synonym |
TNF TNF-a TNF-alpha tumor necrosis factor ligand superfamily member 2 cachectin |
|
| has_related_synonym |
TNFA TNFSF2 |
|
| id |
PR:000000134 |
|
| label |
tumor necrosis factor alpha |
|
| notation |
PR:000000134 |
|
| note |
A tumor necrosis factor, TNF-like that is a translation product of the TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. Category=gene. |
|
| preferred label |
tumor necrosis factor alpha |
|
| prefLabel |
tumor necrosis factor alpha |
|
| subClassOf |
http://purl.obolibrary.org/obo/PR_000000001 http://purl.obolibrary.org/obo/PR_000000033 |