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Neuroscience Information Framework (NIF) Standard Ontology
| Preferred Name | pro-B cell | |
| Synonyms |
pre-B cell (Philadelphia nomenclature) pre-pro B cell progenitor B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte pro-B lymphocyte progenitor B-lymphocyte pro-B-cell |
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| Definitions |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. |
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| ID |
http://purl.obolibrary.org/obo/CL_0000826 |
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| comment |
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
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| alternative label |
pre-B cell (Philadelphia nomenclature) pre-pro B cell progenitor B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte pro-B lymphocyte progenitor B-lymphocyte pro-B-cell
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| database_cross_reference |
BTO:0003104
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|
| definition |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
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| develops_from | ||
| has exact synonym |
progenitor B-cell pro-B-lymphocyte progenitor B cell progenitor B lymphocyte pro-B lymphocyte progenitor B-lymphocyte pro-B-cell
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|
| has part | ||
| has_broad_synonym |
pre-pro B cell
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|
| has_related_synonym |
pre-B cell (Philadelphia nomenclature)
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|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
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| label |
pro-B cell
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|
| note |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
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| overlaps | ||
| participates in | ||
| preferred label |
pro-B cell
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| prefixIRI |
CL:0000826
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| prefLabel |
pro-B cell
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| present_in_taxon | ||
| treeView | ||
| subClassOf |
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