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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Proinsulin [Chemical/Ingredient] | |
| Synonyms |
Proinsulin |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000170325 |
|
| altLabel |
Proinsulin
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|
| cui |
C0033362
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| MESH DEFINITION |
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
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| MESH DUI |
D011384
|
|
| MeSH name |
Proinsulin
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|
| MESH UI |
M0017685
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|
| NDFRT kind |
INGREDIENT_KIND
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|
| notation |
N0000170325
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|
| NUI |
N0000170325
|
|
| prefLabel |
Proinsulin [Chemical/Ingredient]
|
|
| tui |
T116 T123
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| subClassOf |
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