National Drug File - Reference Terminology - Troponin I [Chemical/Ingredient] - Classes

Last uploaded: July 6, 2018

Preferred Name	Troponin I [Chemical/Ingredient]
Synonyms	Troponin I Troponin-I
ID	http://purl.bioontology.org/ontology/NDFRT/N0000169463
altLabel	Troponin I Troponin-I
cui	C0077401
MESH DEFINITION	A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
MESH DUI	D019210
MeSH name	Troponin I
MESH UI	M0028614
NDFRT kind	INGREDIENT_KIND
notation	N0000169463
NUI	N0000169463
prefLabel	Troponin I [Chemical/Ingredient]
tui	T116 T123
subClassOf	http://purl.bioontology.org/ontology/NDFRT/N0000169462

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RCD/X80QX	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/102683006	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/2446-8300	CRISP	CUI
http://purl.bioontology.org/ontology/MESH/D019210	MESH	CUI
http://purl.bioontology.org/ontology/MSHFRE/D019210	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNMI/F-62503	SNMI	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/102683006	SNOMEDCT	CUI