Preferred Name

Apolipoprotein A-I [Chemical/Ingredient]
Synonyms

Apolipoprotein A-1

Apo A-I

ApoA-I

Apo AI

ApoA-1

Apolipoprotein AI

Apolipoprotein A1

Apo A1

Apo A-1

Apolipoprotein A-I

ID

http://purl.bioontology.org/ontology/NDFRT/N0000169008

altLabel

Apolipoprotein A-1

Apo A-I

ApoA-I

Apo AI

ApoA-1

Apolipoprotein AI

Apolipoprotein A1

Apo A1

Apo A-1

Apolipoprotein A-I

cui

C0085201

MESH DEFINITION

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

MESH DUI

D016632

MeSH name

Apolipoprotein A-I

MESH UI

M0025348

NDFRT kind

INGREDIENT_KIND

notation

N0000169008

NUI

N0000169008

prefLabel

Apolipoprotein A-I [Chemical/Ingredient]

tui

T116

T123

subClassOf

http://purl.bioontology.org/ontology/NDFRT/N0000169006

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