loading...| Preferred Name |
Hypoxanthine Phosphoribosyltransferase [Chemical/Ingredient] |
|
| Synonyms |
IMP:pyrophosphate phospho-D-ribosyltransferase HPRT IMP Pyrophosphorylase Hypoxanthine-Guanine Phosphoribosyltransferase HPRTase Hypoxanthine Phosphoribosyltransferase HGPRT Guanine Phosphoribosyltransferase |
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| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000168365 |
|
| altLabel |
IMP:pyrophosphate phospho-D-ribosyltransferase HPRT IMP Pyrophosphorylase Hypoxanthine-Guanine Phosphoribosyltransferase HPRTase Hypoxanthine Phosphoribosyltransferase HGPRT Guanine Phosphoribosyltransferase |
|
| cui |
C0020687 |
|
| MESH DEFINITION |
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8. |
|
| MESH DUI |
D007041 |
|
| MeSH name |
Hypoxanthine Phosphoribosyltransferase |
|
| MESH UI |
M0010952 |
|
| NDFRT kind |
INGREDIENT_KIND |
|
| notation |
N0000168365 |
|
| NUI |
N0000168365 |
|
| prefLabel |
Hypoxanthine Phosphoribosyltransferase [Chemical/Ingredient] |
|
| tui |
T116 T126 |
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| subClassOf |