loading...| Preferred Name | Glucose-6-Phosphate Isomerase [Chemical/Ingredient] | |
| Synonyms |
Glucosephosphate Isomerase Phosphoglucose Isomerase Isomerase, Glucose 6 Phosphate Phosphohexose Isomerase D-Glucose-6-phosphate ketol-isomerase Glucose-6-Phosphate Isomerase |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000168090 |
|
| altLabel |
Glucosephosphate Isomerase Phosphoglucose Isomerase Isomerase, Glucose 6 Phosphate Phosphohexose Isomerase D-Glucose-6-phosphate ketol-isomerase Glucose-6-Phosphate Isomerase |
|
| cui |
C0017759 |
|
| MESH DEFINITION |
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. |
|
| MESH DUI |
D005956 |
|
| MeSH name |
Glucose-6-Phosphate Isomerase |
|
| MESH UI |
M0009354 |
|
| NDFRT kind |
INGREDIENT_KIND |
|
| notation |
N0000168090 |
|
| NUI |
N0000168090 |
|
| prefLabel |
Glucose-6-Phosphate Isomerase [Chemical/Ingredient] |
|
| tui |
T116 T126 |
|
| subClassOf |