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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Hirudins [Chemical/Ingredient] | |
| Synonyms |
Hirudins |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000011205 |
|
| altLabel |
Hirudins
|
|
| cui |
C1451270
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|
| MESH DEFINITION |
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
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|
| MESH DUI |
D006629
|
|
| MeSH name |
Hirudins
|
|
| MESH UI |
M0465835
|
|
| NDFRT kind |
INGREDIENT_KIND
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|
| notation |
N0000011205
|
|
| NUI |
N0000011205
|
|
| prefLabel |
Hirudins [Chemical/Ingredient]
|
|
| tui |
T116 T121
|
|
| subClassOf |
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/MESH/D006629 | MESH | CUI |
| http://purl.bioontology.org/ontology/MSHFRE/D006629 | MSHFRE | CUI |