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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000007364
http://purl.bioontology.org/ontology/NDFRT/N0000007364
|
|---|---|
| Preferred Name | Acetazolamide [Chemical/Ingredient] |
| Synonyms |
Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-
Acetazolamide
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-
Acetazolamide
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|---|---|
| prefLabel | Acetazolamide [Chemical/Ingredient]
|
| notation | N0000007364
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| MESH DEFINITION | One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
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| MESH UI | M0000127
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| subClassOf | |
| Semantic type UMLS property | |
| MeSH name | Acetazolamide
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| NDFRT kind | INGREDIENT_KIND
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| type | |
| tui |
T109
T121
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| NUI | N0000007364
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| cui | C0000981
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| Ingredient of |
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| MESH DUI | D000086
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| Delete | Subject | Author | Type | Created |
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