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National Drug File - Reference Terminology
| Preferred Name | Lovastatin [Chemical/Ingredient] | |
| Synonyms |
Monacolin K Lovastatin 6-Methylcompactin Mevinolin Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- |
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| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000007106 |
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| altLabel |
Monacolin K Lovastatin 6-Methylcompactin Mevinolin Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
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| cui |
C0024027
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| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000164558 http://purl.bioontology.org/ontology/NDFRT/N0000164795 http://purl.bioontology.org/ontology/NDFRT/N0000147602 http://purl.bioontology.org/ontology/NDFRT/N0000164793 http://purl.bioontology.org/ontology/NDFRT/N0000022282 http://purl.bioontology.org/ontology/NDFRT/N0000165746 http://purl.bioontology.org/ontology/NDFRT/N0000164794 http://purl.bioontology.org/ontology/NDFRT/N0000164557 http://purl.bioontology.org/ontology/NDFRT/N0000165744 |
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| MESH DEFINITION |
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
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| MESH DUI |
D008148
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| MeSH name |
Lovastatin
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| MESH UI |
M0012707
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| NDFRT kind |
INGREDIENT_KIND
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| notation |
N0000007106
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| NUI |
N0000007106
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| prefLabel |
Lovastatin [Chemical/Ingredient]
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| tui |
T109 T121
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| subClassOf |
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