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National Drug File - Reference Terminology

Last uploaded: July 6, 2018
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Id http://purl.bioontology.org/ontology/NDFRT/N0000007106
http://purl.bioontology.org/ontology/NDFRT/N0000007106
Preferred Name

Lovastatin [Chemical/Ingredient]
Synonyms
Monacolin K
Lovastatin
6-Methylcompactin
Mevinolin
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Type http://www.w3.org/2002/07/owl#Class

All Properties

altLabel
Monacolin K
Lovastatin
6-Methylcompactin
Mevinolin
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
prefLabel
Lovastatin [Chemical/Ingredient]
notation
N0000007106
MESH DEFINITION
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
MESH UI
M0012707
subClassOf
Semantic type UMLS property
MeSH name
Lovastatin
NDFRT kind
INGREDIENT_KIND
type
tui
T109
T121
NUI
N0000007106
cui
C0024027
Ingredient of
MESH DUI
D008148
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