National Drug File - Reference Terminology

Last uploaded: July 6, 2018
Id http://purl.bioontology.org/ontology/NDFRT/N0000007106
http://purl.bioontology.org/ontology/NDFRT/N0000007106
Preferred Name

Lovastatin [Chemical/Ingredient]
Synonyms
Monacolin K
Lovastatin
6-Methylcompactin
Mevinolin
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Type http://www.w3.org/2002/07/owl#Class

All Properties

altLabel
Monacolin K
Lovastatin
6-Methylcompactin
Mevinolin
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
prefLabel
Lovastatin [Chemical/Ingredient]
MESH DEFINITION
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
MESH DUI
D008148
MESH UI
M0012707
MeSH name
Lovastatin
type
tui
T109
T121
notation
N0000007106
Semantic type UMLS property
NUI
N0000007106
Ingredient of
cui
C0024027
NDFRT kind
INGREDIENT_KIND
subClassOf
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