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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006933
http://purl.bioontology.org/ontology/NDFRT/N0000006933
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|---|---|
| Preferred Name | Zidovudine [Chemical/Ingredient] |
| Synonyms |
AZT Antiviral
Zidovudine
Thymidine, 3'-azido-3'-deoxy-
Azidothymidine
AZT, Antiviral
AZT (Antiviral)
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
AZT Antiviral
Zidovudine
Thymidine, 3'-azido-3'-deoxy-
Azidothymidine
AZT, Antiviral
AZT (Antiviral)
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
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|
|---|---|
| prefLabel |
Zidovudine [Chemical/Ingredient]
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| notation |
N0000006933
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| MESH DEFINITION |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
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| MESH UI |
M0023377
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| subClassOf | |
| Semantic type UMLS property | |
| MeSH name |
Zidovudine
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| NDFRT kind |
INGREDIENT_KIND
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| type | |
| tui |
T114
T121
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| NUI |
N0000006933
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| cui |
C0043474
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| Ingredient of |
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|
| MESH DUI |
D015215
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