National Drug File - Reference Terminology

Last uploaded: July 6, 2018
Id http://purl.bioontology.org/ontology/NDFRT/N0000006933
http://purl.bioontology.org/ontology/NDFRT/N0000006933
Preferred Name

Zidovudine [Chemical/Ingredient]
Synonyms
AZT Antiviral
Zidovudine
Thymidine, 3'-azido-3'-deoxy-
Azidothymidine
AZT, Antiviral
AZT (Antiviral)
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
Type http://www.w3.org/2002/07/owl#Class

All Properties

altLabel
AZT Antiviral
Zidovudine
Thymidine, 3'-azido-3'-deoxy-
Azidothymidine
AZT, Antiviral
AZT (Antiviral)
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
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prefLabel
Zidovudine [Chemical/Ingredient]
MESH DEFINITION
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
MESH DUI
D015215
MESH UI
M0023377
MeSH name
Zidovudine
type
tui
T114
T121
notation
N0000006933
Semantic type UMLS property
NUI
N0000006933
Ingredient of
cui
C0043474
NDFRT kind
INGREDIENT_KIND
subClassOf
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