National Drug File - Reference Terminology - Dactinomycin [Chemical/Ingredient] - Classes

Last uploaded: July 6, 2018

Id	http://purl.bioontology.org/ontology/NDFRT/N0000006852 http://purl.bioontology.org/ontology/NDFRT/N0000006852
Preferred Name	Dactinomycin [Chemical/Ingredient]
Synonyms	Actinomycin D Meractinomycin Dactinomycin
Type	http://www.w3.org/2002/07/owl#Class

altLabel	Actinomycin D Meractinomycin Dactinomycin
prefLabel	Dactinomycin [Chemical/Ingredient]
notation	N0000006852
MESH DEFINITION	A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
MESH UI	M0005644
subClassOf	http://purl.bioontology.org/ontology/NDFRT/N0000008096
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T116 http://purl.bioontology.org/ontology/STY/T195
MeSH name	Dactinomycin
NDFRT kind	INGREDIENT_KIND
type	http://www.w3.org/2002/07/owl#Class
tui	T195 T116
NUI	N0000006852
cui	C0010934
Ingredient of	http://purl.bioontology.org/ontology/NDFRT/N0000146314 http://purl.bioontology.org/ontology/NDFRT/N0000151108
MESH DUI	D003609

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