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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006852
http://purl.bioontology.org/ontology/NDFRT/N0000006852
|
|---|---|
| Preferred Name | Dactinomycin [Chemical/Ingredient] |
| Synonyms |
Actinomycin D
Meractinomycin
Dactinomycin
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Actinomycin D
Meractinomycin
Dactinomycin
|
|---|---|
| prefLabel | Dactinomycin [Chemical/Ingredient]
|
| notation | N0000006852
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| MESH DEFINITION | A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
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| MESH UI | M0005644
|
| subClassOf | |
| Semantic type UMLS property | |
| MeSH name | Dactinomycin
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| NDFRT kind | INGREDIENT_KIND
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| type | |
| tui |
T195
T116
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| NUI | N0000006852
|
| cui | C0010934
|
| Ingredient of | |
| MESH DUI | D003609
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| Delete | Subject | Author | Type | Created |
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| No notes to display |