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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006798
http://purl.bioontology.org/ontology/NDFRT/N0000006798
|
|---|---|
| Preferred Name | Etoposide [Chemical/Ingredient] |
| Synonyms |
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Eposide
Etoposide
Demethyl Epipodophyllotoxin Ethylidine Glucoside
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Eposide
Etoposide
Demethyl Epipodophyllotoxin Ethylidine Glucoside
|
|---|---|
| prefLabel |
Etoposide [Chemical/Ingredient]
|
| notation |
N0000006798
|
| MESH DEFINITION |
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
|
| MESH UI |
M0007930
|
| subClassOf | |
| Semantic type UMLS property | |
| MeSH name |
Etoposide
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| NDFRT kind |
INGREDIENT_KIND
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| type | |
| tui |
T109
T121
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| NUI |
N0000006798
|
| cui |
C0015133
|
| Ingredient of | |
| MESH DUI |
D005047
|
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