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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006772
http://purl.bioontology.org/ontology/NDFRT/N0000006772
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|---|---|
| Preferred Name | Amiloride [Chemical/Ingredient] |
| Synonyms |
Amiloride
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Amiloride
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
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|---|---|
| prefLabel | Amiloride [Chemical/Ingredient]
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| MESH DEFINITION | A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
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| MESH DUI | D000584
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| MESH UI | M0000906
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| MeSH name | Amiloride
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| type | |
| tui |
T109
T121
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| Contraindicating class of | |
| notation | N0000006772
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| Semantic type UMLS property | |
| NUI | N0000006772
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| Ingredient of | |
| cui | C0002502
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| NDFRT kind | INGREDIENT_KIND
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |