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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006585
http://purl.bioontology.org/ontology/NDFRT/N0000006585
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|---|---|
| Preferred Name | Clozapine [Chemical/Ingredient] |
| Synonyms |
Clozapine
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Clozapine
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
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|---|---|
| prefLabel | Clozapine [Chemical/Ingredient]
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| MESH DEFINITION | A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
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| MESH DUI | D003024
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| MESH UI | M0004649
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| MeSH name | Clozapine
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| type | |
| tui |
T109
T121
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| notation | N0000006585
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| Semantic type UMLS property | |
| NUI | N0000006585
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| Ingredient of |
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| cui | C0009079
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| NDFRT kind | INGREDIENT_KIND
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| subClassOf |
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