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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Thalidomide [Chemical/Ingredient] | |
| Synonyms |
Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006367 |
|
| altLabel |
Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
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|
| cui |
C0039736
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|
| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000161190 http://purl.bioontology.org/ontology/NDFRT/N0000164307 http://purl.bioontology.org/ontology/NDFRT/N0000148588 |
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| MESH DEFINITION |
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
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| MESH DUI |
D013792
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| MeSH name |
Thalidomide
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|
| MESH UI |
M0021267
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| NDFRT kind |
INGREDIENT_KIND
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| notation |
N0000006367
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|
| NUI |
N0000006367
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|
| prefLabel |
Thalidomide [Chemical/Ingredient]
|
|
| tui |
T109 T131 T121
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| subClassOf |
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