loading...| Preferred Name |
Thalidomide [Chemical/Ingredient] |
|
| Synonyms |
Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006367 |
|
| altLabel |
Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- |
|
| cui |
C0039736 |
|
| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000161190 http://purl.bioontology.org/ontology/NDFRT/N0000164307 http://purl.bioontology.org/ontology/NDFRT/N0000148588 |
|
| MESH DEFINITION |
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. |
|
| MESH DUI |
D013792 |
|
| MeSH name |
Thalidomide |
|
| MESH UI |
M0021267 |
|
| NDFRT kind |
INGREDIENT_KIND |
|
| notation |
N0000006367 |
|
| NUI |
N0000006367 |
|
| prefLabel |
Thalidomide [Chemical/Ingredient] |
|
| tui |
T109 T131 T121 |
|
| subClassOf |