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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Cilastatin [Chemical/Ingredient] | |
| Synonyms |
2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))- Cilastatin |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006280 |
|
| altLabel |
2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))- Cilastatin
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|
| cui |
C0008777
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|
| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000147771 |
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| MESH DEFINITION |
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
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|
| MESH DUI |
D015377
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|
| MeSH name |
Cilastatin
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|
| MESH UI |
M0023687
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|
| NDFRT kind |
INGREDIENT_KIND
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|
| notation |
N0000006280
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|
| NUI |
N0000006280
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|
| prefLabel |
Cilastatin [Chemical/Ingredient]
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|
| tui |
T109 T121
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| subClassOf |
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