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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006280
http://purl.bioontology.org/ontology/NDFRT/N0000006280
|
|---|---|
| Preferred Name | Cilastatin [Chemical/Ingredient] |
| Synonyms |
2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-
Cilastatin
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel | 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-
Cilastatin
|
|---|---|
| prefLabel | Cilastatin [Chemical/Ingredient]
|
| MESH DEFINITION | A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
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| MESH DUI | D015377
|
| MESH UI | M0023687
|
| MeSH name | Cilastatin
|
| type | |
| tui |
T109
T121
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| notation | N0000006280
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| Semantic type UMLS property | |
| NUI | N0000006280
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| Ingredient of | |
| cui | C0008777
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| NDFRT kind | INGREDIENT_KIND
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |