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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006251
http://purl.bioontology.org/ontology/NDFRT/N0000006251
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|---|---|
| Preferred Name | Anistreplase [Chemical/Ingredient] |
| Synonyms |
Anistreplase
APSAC
Anisoylated Plasminogen-Streptokinase Activator Complex
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Anistreplase
APSAC
Anisoylated Plasminogen-Streptokinase Activator Complex
|
|---|---|
| prefLabel | Anistreplase [Chemical/Ingredient]
|
| MESH DEFINITION | An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.
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| MESH DUI | D016255
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| MESH UI | M0024829
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| MeSH name | Anistreplase
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| type | |
| tui |
T116
T126
T121
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| notation | N0000006251
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| Semantic type UMLS property | |
| NUI | N0000006251
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| Ingredient of | |
| cui | C0078956
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| NDFRT kind | INGREDIENT_KIND
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| subClassOf |
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| No notes to display |