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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Teniposide [Chemical/Ingredient] | |
| Synonyms |
Teniposide Demethyl Epipodophyllotoxin Thenylidine Glucoside Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))- |
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| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006147 |
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| altLabel |
Teniposide Demethyl Epipodophyllotoxin Thenylidine Glucoside Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
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| cui |
C0039512
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| Ingredient of | ||
| MESH DEFINITION |
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
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| MESH DUI |
D013713
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| MeSH name |
Teniposide
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| MESH UI |
M0021161
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| NDFRT kind |
INGREDIENT_KIND
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| notation |
N0000006147
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| NUI |
N0000006147
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| prefLabel |
Teniposide [Chemical/Ingredient]
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| tui |
T109 T121
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| subClassOf |
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