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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006111
http://purl.bioontology.org/ontology/NDFRT/N0000006111
|
|---|---|
| Preferred Name | Didanosine [Chemical/Ingredient] |
| Synonyms |
Dideoxyinosine
Inosine, 2',3'-dideoxy-
Didanosine
ddI (Antiviral)
2',3'-Dideoxyinosine
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Dideoxyinosine
Inosine, 2',3'-dideoxy-
Didanosine
ddI (Antiviral)
2',3'-Dideoxyinosine
|
|---|---|
| prefLabel | Didanosine [Chemical/Ingredient]
|
| notation | N0000006111
|
| MESH DEFINITION | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
|
| MESH UI | M0024535
|
| subClassOf | |
| Semantic type UMLS property | |
| MeSH name | Didanosine
|
| NDFRT kind | INGREDIENT_KIND
|
| type | |
| tui |
T114
T121
|
| NUI | N0000006111
|
| cui | C0012133
|
| Ingredient of | |
| MESH DUI | D016049
|
| Delete | Subject | Author | Type | Created |
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| No notes to display |