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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000006107
http://purl.bioontology.org/ontology/NDFRT/N0000006107
|
|---|---|
| Preferred Name | Zalcitabine [Chemical/Ingredient] |
| Synonyms |
Dideoxycytidine
2',3'-Dideoxycytidine
Cytidine, 2',3'-dideoxy-
ddC (Antiviral)
Zalcitabine
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Dideoxycytidine
2',3'-Dideoxycytidine
Cytidine, 2',3'-dideoxy-
ddC (Antiviral)
Zalcitabine
|
|---|---|
| prefLabel | Zalcitabine [Chemical/Ingredient]
|
| MESH DEFINITION | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
|
| MESH DUI | D016047
|
| MESH UI | M0024532
|
| MeSH name | Zalcitabine
|
| type | |
| tui |
T114
T121
|
| notation | N0000006107
|
| Semantic type UMLS property | |
| NUI | N0000006107
|
| Ingredient of | |
| cui | C0012132
|
| NDFRT kind | INGREDIENT_KIND
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |