National Drug File - Reference Terminology - Spironolactone [Chemical/Ingredient] - Classes | NCBO BioPortal

National Drug File - Reference Terminology

Last uploaded: July 6, 2018

Preferred Name	Spironolactone [Chemical/Ingredient]
Synonyms	Spirolactone Verospirone Veroshpiron Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)- Spironolactone
ID	http://purl.bioontology.org/ontology/NDFRT/N0000005900
altLabel	Spirolactone Verospirone Veroshpiron Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)- Spironolactone
Contraindicating class of	http://purl.bioontology.org/ontology/NDFRT/N0000147699 http://purl.bioontology.org/ontology/NDFRT/N0000146285 http://purl.bioontology.org/ontology/NDFRT/N0000150992 http://purl.bioontology.org/ontology/NDFRT/N0000146253 http://purl.bioontology.org/ontology/NDFRT/N0000155571 http://purl.bioontology.org/ontology/NDFRT/N0000155572
cui	C0037982
Ingredient of	http://purl.bioontology.org/ontology/NDFRT/N0000165580 http://purl.bioontology.org/ontology/NDFRT/N0000020141 http://purl.bioontology.org/ontology/NDFRT/N0000193648 http://purl.bioontology.org/ontology/NDFRT/N0000150797 http://purl.bioontology.org/ontology/NDFRT/N0000146234 http://purl.bioontology.org/ontology/NDFRT/N0000165579 http://purl.bioontology.org/ontology/NDFRT/N0000165578 http://purl.bioontology.org/ontology/NDFRT/N0000150798 http://purl.bioontology.org/ontology/NDFRT/N0000162323 http://purl.bioontology.org/ontology/NDFRT/N0000150840
MESH DEFINITION	A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
MESH DUI	D013148
MeSH name	Spironolactone
MESH UI	M0020352
NDFRT kind	INGREDIENT_KIND
notation	N0000005900
NUI	N0000005900
prefLabel	Spironolactone [Chemical/Ingredient]
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/NDFRT/N0000007646

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D013148	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/387078006	SCTSPA	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000039444	PDQ	CUI
http://purl.bioontology.org/ontology/LNC/MTHU003227	LOINC	CUI
http://purl.bioontology.org/ontology/RCD/b43..	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/13929005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/13929005	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/9997	RXNORM	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387078006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/ATC/C03DA01	ATC	CUI
http://purl.bioontology.org/ontology/VANDF/4017881	VANDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-72420	SNMI	CUI
http://purl.bioontology.org/ontology/LNC/LP16280-7	LOINC	CUI
http://purl.bioontology.org/ontology/CSP/2794-2536	CRISP	CUI
http://purl.bioontology.org/ontology/MESH/D013148	MESH	CUI
http://purl.bioontology.org/ontology/NDDF/002211	NDDF	CUI