National Drug File - Reference Terminology

Last uploaded: July 6, 2018
Id http://purl.bioontology.org/ontology/NDFRT/N0000005900
http://purl.bioontology.org/ontology/NDFRT/N0000005900
Preferred Name

Spironolactone [Chemical/Ingredient]
Synonyms
Spirolactone
Verospirone
Veroshpiron
Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
Spironolactone
Type http://www.w3.org/2002/07/owl#Class

All Properties

altLabel
Spirolactone
Verospirone
Veroshpiron
Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
Spironolactone
prefLabel
Spironolactone [Chemical/Ingredient]
notation
N0000005900
MESH DEFINITION
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
MESH UI
M0020352
Contraindicating class of
subClassOf
Semantic type UMLS property
MeSH name
Spironolactone
NDFRT kind
INGREDIENT_KIND
type
tui
T109
T121
NUI
N0000005900
cui
C0037982
Ingredient of
MESH DUI
D013148
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