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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Disulfiram [Chemical/Ingredient] | |
| Synonyms |
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 Tetraethylthiuram Disulfide Disulfiram Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl- Bis(diethylthiocarbamoyl) Disulfide |
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| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000005851 |
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| altLabel |
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 Tetraethylthiuram Disulfide Disulfiram Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl- Bis(diethylthiocarbamoyl) Disulfide
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| Contraindicating class of |
http://purl.bioontology.org/ontology/NDFRT/N0000147772 |
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| cui |
C0012772
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| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000153055 |
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| MESH DEFINITION |
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
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| MESH DUI |
D004221
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| MeSH name |
Disulfiram
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| MESH UI |
M0006600
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| NDFRT kind |
INGREDIENT_KIND
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| notation |
N0000005851
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| NUI |
N0000005851
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| prefLabel |
Disulfiram [Chemical/Ingredient]
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| tui |
T109 T121
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| subClassOf |
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