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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000005842
http://purl.bioontology.org/ontology/NDFRT/N0000005842
|
|---|---|
| Preferred Name | Simvastatin [Chemical/Ingredient] |
| Synonyms |
Simvastatin
Synvinolin
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Simvastatin
Synvinolin
|
|---|---|
| prefLabel | Simvastatin [Chemical/Ingredient]
|
| MESH DEFINITION | A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
|
| MESH DUI | D019821
|
| MESH UI | M0029425
|
| MeSH name | Simvastatin
|
| type | |
| tui |
T109
T121
|
| Contraindicating class of |
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| notation | N0000005842
|
| Semantic type UMLS property | |
| NUI | N0000005842
|
| Ingredient of |
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|
| cui |
C4082576
C0074554
|
| NDFRT kind | INGREDIENT_KIND
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |