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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000004422
http://purl.bioontology.org/ontology/NDFRT/N0000004422
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|---|---|
| Preferred Name | Botulinum Toxins [Chemical/Ingredient] |
| Synonyms |
Botulinum Toxins
Clostridium botulinum Toxins
Botulin
Botulinum Toxin
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Botulinum Toxins
Clostridium botulinum Toxins
Botulin
Botulinum Toxin
|
|---|---|
| prefLabel | Botulinum Toxins [Chemical/Ingredient]
|
| MESH DEFINITION | Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
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| MESH DUI | D001905
|
| MESH UI | M0002844
|
| MeSH name | Botulinum Toxins
|
| type | |
| tui |
T116
T131
T121
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| notation | N0000004422
|
| Semantic type UMLS property | |
| NUI | N0000004422
|
| cui | C0006055
|
| NDFRT kind | INGREDIENT_KIND
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |