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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000002172
http://purl.bioontology.org/ontology/NDFRT/N0000002172
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|---|---|
| Preferred Name | Neuroleptic Malignant Syndrome [Disease/Finding] |
| Synonyms |
Neuroleptic Malignant Syndrome
NMS (Neuroleptic Malignant Syndrome)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Neuroleptic Malignant Syndrome
NMS (Neuroleptic Malignant Syndrome)
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|---|---|
| prefLabel | Neuroleptic Malignant Syndrome [Disease/Finding]
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| MESH DEFINITION | A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
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| MESH DUI | D009459
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| MESH UI | M0014713
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| MeSH name | Neuroleptic Malignant Syndrome
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| type | |
| tui | T047
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| SNOMED CID | 15244003
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| May be treated by |
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| notation | N0000002172
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| Semantic type UMLS property | |
| NUI | N0000002172
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| cui | C0027849
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| NDFRT kind | DISEASE_KIND
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| subClassOf |
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| No notes to display |