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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
| Id | http://purl.bioontology.org/ontology/NDFRT/N0000000376
http://purl.bioontology.org/ontology/NDFRT/N0000000376
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|---|---|
| Preferred Name | Amyotrophic Lateral Sclerosis [Disease/Finding] |
| Synonyms |
Lou-Gehrigs Disease
Lou Gehrig's Disease
Lou Gehrig Disease
Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Gehrig's Disease
Charcot Disease
ALS (Amyotrophic Lateral Sclerosis)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel |
Lou-Gehrigs Disease
Lou Gehrig's Disease
Lou Gehrig Disease
Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Gehrig's Disease
Charcot Disease
ALS (Amyotrophic Lateral Sclerosis)
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| prefLabel | Amyotrophic Lateral Sclerosis [Disease/Finding]
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| MESH DEFINITION | A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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| MESH DUI | D000690
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| MESH UI | M0001056
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| MeSH name | Amyotrophic Lateral Sclerosis
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| type | |
| tui | T047
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| SNOMED CID | 86044005
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| May be treated by | |
| notation | N0000000376
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| Semantic type UMLS property | |
| NUI | N0000000376
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| cui | C0002736
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| NDFRT kind | DISEASE_KIND
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |