loading...| Preferred Name |
Quinine |
|
| Synonyms |
(-)-Quinine QUIN QUININE Quinine |
|
| Definitions |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C794 |
|
| CAS_Registry |
130-95-0 |
|
| CHEBI_ID |
CHEBI:15854 |
|
| Chemical_Formula |
C20H24N2O2 |
|
| code |
C794 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|
| FDA_UNII_Code |
A7V27PHC7A |
|
| FULL_SYN |
(-)-Quinine QUIN QUININE Quinine |
|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75269 |
|
| Is_Value_For_GDC_Property | ||
| label |
Quinine |
|
| Legacy Concept Name |
Quinine |
|
| Maps_To |
Quinine |
|
| NCI_Drug_Dictionary_ID |
41253 |
|
| NSC Number |
192949 |
|
| PDQ_Closed_Trial_Search_ID |
41253 |
|
| PDQ_Open_Trial_Search_ID |
41253 |
|
| Preferred_Name |
Quinine |
|
| prefixIRI |
Thesaurus:C794 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0034417 |
|
| subClassOf |