National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Calcifediol Anhydrous
Synonyms

9,10-Secocholesta-5,7,10(19)-Triene-3beta,25-Diol

(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol

(3S,5Z,7E)-9,10-Secocholesta-5,7,10-Triene-3,25-Diol

25-Hydroxyvitamin D

Cholecalciferol, 25-Hydroxy-

25-Hydroxyvitamin D3

CALCIFEDIOL ANHYDROUS

9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol, (3beta,5Z,7E)-

(5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol

25-Hydroxycholescalciferol

Calcifediol Anhydrous

5,6-trans-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol

5,6-cis-25-Hydroxyvitamin D3

5,6-trans-25-Hydroxycholescalciferol

25-Hydroxycholecalciferol

(5Z,7E)-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol

25(OH)D3

Calcidiol
Definitions

The anhydrous form of calcifediol, an orally available synthetic form of the calcitriol prohormone calcifediol (25-hydroxyvitamin D), which can be used for vitamin D supplementation, and with potential immunomodulating activity. Upon oral administration, calcifediol is taken up by the body and converted, in the kidneys, to the active form calcitriol (1,25-dihydroxyvitamin D or 1,25(OH)2D). This form increases and normalizes vitamin D plasma levels, which, in turn, regulates calcium plasma levels, and normalizes elevated parathyroid hormone (PTH) levels by suppressing both PTH synthesis, and secretion. Vitamin D modulates and enhances the innate and adaptive immune responses. This may improve unregulated inflammation and prevents the production of pro-inflammatory cytokines. Specifically, vitamin D binds to its receptor vitamin D receptor (VDR) which is widely expressed on immune cells and epithelial cells. This stimulates neutrophils, macrophages, and natural killer (NK) cells, and activates epithelial cells to produce antimicrobial peptides (AMPs). In addition, upon infection, vitamin D promotes the migration of myeloid dendritic cells (mDCs) to lymphoid organs where they activate B- and T-lymphocytes.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77155
CAS_Registry

19356-17-3
CHEBI_ID

CHEBI:17933
Chemical_Formula

C27H44O2
code

C77155
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

The anhydrous form of calcifediol, an orally available synthetic form of the calcitriol prohormone calcifediol (25-hydroxyvitamin D), which can be used for vitamin D supplementation, and with potential immunomodulating activity. Upon oral administration, calcifediol is taken up by the body and converted, in the kidneys, to the active form calcitriol (1,25-dihydroxyvitamin D or 1,25(OH)2D). This form increases and normalizes vitamin D plasma levels, which, in turn, regulates calcium plasma levels, and normalizes elevated parathyroid hormone (PTH) levels by suppressing both PTH synthesis, and secretion. Vitamin D modulates and enhances the innate and adaptive immune responses. This may improve unregulated inflammation and prevents the production of pro-inflammatory cytokines. Specifically, vitamin D binds to its receptor vitamin D receptor (VDR) which is widely expressed on immune cells and epithelial cells. This stimulates neutrophils, macrophages, and natural killer (NK) cells, and activates epithelial cells to produce antimicrobial peptides (AMPs). In addition, upon infection, vitamin D promotes the migration of myeloid dendritic cells (mDCs) to lymphoid organs where they activate B- and T-lymphocytes.
Display_Name

Calcifediol Anhydrous
FDA_UNII_Code

T0WXW8F54E
FULL_SYN

9,10-Secocholesta-5,7,10(19)-Triene-3beta,25-Diol

(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol

(3S,5Z,7E)-9,10-Secocholesta-5,7,10-Triene-3,25-Diol

25-Hydroxyvitamin D

Cholecalciferol, 25-Hydroxy-

25-Hydroxyvitamin D3

CALCIFEDIOL ANHYDROUS

9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol, (3beta,5Z,7E)-

(5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol

25-Hydroxycholescalciferol

Calcifediol Anhydrous

5,6-trans-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol

5,6-cis-25-Hydroxyvitamin D3

5,6-trans-25-Hydroxycholescalciferol

25-Hydroxycholecalciferol

(5Z,7E)-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol

25(OH)D3

Calcidiol
label

Calcifediol Anhydrous
Legacy Concept Name

Calcifediol_Anhydrous
Preferred_Name

Calcifediol Anhydrous
prefixIRI

Thesaurus:C77155
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0535968
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39713
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