National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Recombinant Oxytocin

Synonyms

Recombinant Oxytocin

OXYTOCIN

Oxytocin

Pitocin

Syntocinon

Definitions

A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C724

CAS_Registry

50-56-6

CHEBI_ID

CHEBI:7872

Chemical_Formula

C43H66N12O12S2

code

C724

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13236

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation.

Display_Name

Recombinant Oxytocin

FDA_UNII_Code

1JQS135EYN

FULL_SYN

Recombinant Oxytocin

OXYTOCIN

Oxytocin

Pitocin

Syntocinon

label

Recombinant Oxytocin

Legacy Concept Name

Therapeutic_Oxytocin

NCI_Drug_Dictionary_ID

39293

PDQ_Closed_Trial_Search_ID

39293

PDQ_Open_Trial_Search_ID

39293

Preferred_Name

Recombinant Oxytocin

prefixIRI

Thesaurus:C724

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

UMLS_CUI

C0733348

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2348

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