loading...| Preferred Name |
Ofloxacin |
|
| Synonyms |
9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL- DL-8280 Floxin HOE 280 OFLOXACIN Ocuflox Ofloxacin ofloxacin |
|
| Definitions |
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C712 |
|
| Accepted_Therapeutic_Use_For |
Various bacterial infections |
|
| ALT_DEFINITION |
An antibiotic drug used to treat infection. It belongs to the family of drugs called quinolone antibiotics. |
|
| CAS_Registry |
82419-36-1 83380-47-6 |
|
| CHEBI_ID |
CHEBI:7731 |
|
| Chemical_Formula |
C18H20FN3O4 |
|
| code |
C712 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04) |
|
| FDA_UNII_Code |
A4P49JAZ9H |
|
| FULL_SYN |
9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL- DL-8280 Floxin HOE 280 OFLOXACIN Ocuflox Ofloxacin ofloxacin |
|
| label |
Ofloxacin |
|
| Legacy Concept Name |
Ofloxacin |
|
| NCI_Drug_Dictionary_ID |
42865 |
|
| NSC Number |
727071 |
|
| PDQ_Closed_Trial_Search_ID |
42865 |
|
| PDQ_Open_Trial_Search_ID |
42865 |
|
| Preferred_Name |
Ofloxacin |
|
| prefixIRI |
Thesaurus:C712 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0028902 |
|
| subClassOf |