loading...| Preferred Name |
Methotrexate |
|
| Synonyms |
Methotrexate LPF methotrexate Farmitrexat 4-Amino-10-methylfolic Acid 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid Methotrexate Methylaminopterin Medsatrexate Methotrexatum Metotrexato METHOTREXATE Alpha-Methopterin Methoblastin amethopterin Methotrexate N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Ledertrexate Amethopterin Abitrexate Brimexate CL 14377 CL-14377 Emtexate Emthexat Emthexate Fauldexato Folex Folex PFS Lantarel Lumexon MTX Maxtrex Metex Metrotex Mexate Mexate-AQ Novatrex Rheumatrex Texate Tremetex Trexeron Trixilem WR-19039 |
|
| Definitions |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C642 |
|
| Accepted_Therapeutic_Use_For |
Graft versus host disease-prophylaxis; Head/neck cancer; Hydatidiform mole; Leukemia; meningeal; Lymphomas; Acute Lymphoblastic Leukemia; Burkitt's; Lung cancer; Mycosis fungoides; Osteosarcoma; Psoriasis; Rheumatoid arthritis; Wegener's granulomatosis Abortion; Bladder cancer; Breast cancer; Carcinomatous; meningitis; Chorioadenoma destruens; Crohn's disease; Ectopic pregnancy; Esophageal cancer; Gestational choriocarcinoma |
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| ALT_DEFINITION |
A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. |
|
| CAS_Registry |
59-05-2 |
|
| CHEBI_ID |
CHEBI:44185 |
|
| Chemical_Formula |
C20H22N8O5 |
|
| code |
C642 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. |
|
| Display_Name |
Methotrexate |
|
| FDA_UNII_Code |
YL5FZ2Y5U1 |
|
| FULL_SYN |
Methotrexate LPF methotrexate Farmitrexat 4-Amino-10-methylfolic Acid 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid Methotrexate Methylaminopterin Medsatrexate Methotrexatum Metotrexato METHOTREXATE Alpha-Methopterin Methoblastin amethopterin Methotrexate N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Ledertrexate Amethopterin Abitrexate Brimexate CL 14377 CL-14377 Emtexate Emthexat Emthexate Fauldexato Folex Folex PFS Lantarel Lumexon MTX Maxtrex Metex Metrotex Mexate Mexate-AQ Novatrex Rheumatrex Texate Tremetex Trexeron Trixilem WR-19039 |
|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Methotrexate |
|
| Legacy Concept Name |
Methotrexate |
|
| Maps_To |
Methotrexate |
|
| NCI_Drug_Dictionary_ID |
41719 |
|
| NSC Number |
740 |
|
| PDQ_Closed_Trial_Search_ID |
41719 |
|
| PDQ_Open_Trial_Search_ID |
41719 |
|
| Preferred_Name |
Methotrexate |
|
| prefixIRI |
Thesaurus:C642 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0025677 |
|
| subClassOf |