National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Diphenhydramine

Synonyms

Diphenhydramine

2-(Diphenylmethoxy)-N,N-dimethylethylamine

diphenhydramine

DIPHENHYDRAMINE

O-Benzhydryldimethylaminoethanol

FAR 90X2

PM 255

Probedryl

Rigidyl

S51

Syntedril

Definitions

A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61728

ALT_DEFINITION

A drug used to treat allergies and relieve cough and itching caused by insect bites, sunburn, and poison oak or ivy. It is also used to treat mild Parkinson disease, to prevent and treat motion sickness, to relieve cough and cold symptoms, and as a sleep aid. It is a type of antihistamine.

CAS_Registry

58-73-1

CHEBI_ID

CHEBI:4636

Chemical_Formula

C17H21NO

code

C61728

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

HemOnc

DEFINITION

A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

Display_Name

Diphenhydramine

FDA_UNII_Code

8GTS82S83M

FULL_SYN

Diphenhydramine

2-(Diphenylmethoxy)-N,N-dimethylethylamine

diphenhydramine

DIPHENHYDRAMINE

O-Benzhydryldimethylaminoethanol

FAR 90X2

PM 255

Probedryl

Rigidyl

S51

Syntedril

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82274

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97698

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C300

label

Diphenhydramine

Legacy Concept Name

Diphenhydramine

Preferred_Name

Diphenhydramine

prefixIRI

Thesaurus:C61728

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0012522

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C267

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29578

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001153 XCO LOOM
http://purl.bioontology.org/ontology/LNC/LP16116-3 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-51450 SNMI LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Diphenhydramine STMSO LOOM
http://purl.bioontology.org/ontology/VANDF/4019724 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3981 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147816 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4636 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/3498 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004155 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907087207661757 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C61728 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.320 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012522 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU063001 LOINC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Diphenhydramine APAONTO LOOM
http://www.drugbank.ca/drugs/DB01075 FTC LOOM
http://purl.bioontology.org/ontology/ATC/R06AA02 ATC LOOM
http://purl.bioontology.org/ontology/RCD/X79JE RCD LOOM
http://purl.bioontology.org/ontology/ATC/D04AA32 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0005419 OMIT LOOM
http://purl.bioontology.org/ontology/MESH/D004155 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016145 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/MESH_D004155 BERO LOOM
https://go.drugbank.com/drugs/DB01075 MDM LOOM
http://purl.jp/bio/4/id/200906078038850194 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/004787 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.115.250 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372682005 SNOMEDCT LOOM