loading...| Preferred Name |
Ifosfamide |
|
| Synonyms |
Asta Z 4942 Iso-Endoxan Iphosphamid 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine Iphosphamide N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide Ifosfamidum Asta Z-4942 Isophosphamide Cyfos Holoxan Holoxane IFO IFO-Cell IFOSFAMIDE IFX Ifex Ifolem Ifomida Ifomide Ifosfamide Ifoxan Isoendoxan MJF 9325 MJF-9325 Mitoxana Naxamide Seromida Tronoxal Z 4942 Z-4942 ifosfamide |
|
| Definitions |
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 |
|
| Accepted_Therapeutic_Use_For |
Breast cancer; gastric carcinoma; lung cancer; lymphocytic leukemias; lymphoma; Hodgkins and Non-Hodgkins; ovarian cancer; pancreatic carcinoma; sarcomas; testicular cancer |
|
| ALT_DEFINITION |
A drug that is used with other drugs to treat germ cell testicular cancer that did not respond to previous treatment with other drugs. It is also being studied in the treatment of other types of cancer. Ifex attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent and a type of antimetabolite. |
|
| CAS_Registry |
3778-73-2 |
|
| CHEBI_ID |
CHEBI:5864 |
|
| Chemical_Formula |
C7H15Cl2N2O2P |
|
| code |
C564 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04) |
|
| Display_Name |
Ifosfamide |
|
| FDA_UNII_Code |
UM20QQM95Y |
|
| FULL_SYN |
Asta Z 4942 Iso-Endoxan Iphosphamid 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine Iphosphamide N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide Ifosfamidum Asta Z-4942 Isophosphamide Cyfos Holoxan Holoxane IFO IFO-Cell IFOSFAMIDE IFX Ifex Ifolem Ifomida Ifomide Ifosfamide Ifoxan Isoendoxan MJF 9325 MJF-9325 Mitoxana Naxamide Seromida Tronoxal Z 4942 Z-4942 ifosfamide |
|
| Is_PCDC_GCT_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Ifosfamide |
|
| Legacy Concept Name |
Ifosfamide |
|
| Maps_To |
Ifosfamide |
|
| NCI_Drug_Dictionary_ID |
40024 |
|
| NSC Number |
109724 |
|
| PDQ_Closed_Trial_Search_ID |
40024 |
|
| PDQ_Open_Trial_Search_ID |
40024 |
|
| Preferred_Name |
Ifosfamide |
|
| prefixIRI |
Thesaurus:C564 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0020823 |
|
| subClassOf |