Preferred Name |
Ibuprofen |
|
Synonyms |
Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)- p-Isobutylhydratropic acid p-Isobutylhydratropic Acid (.+ -.)-p-Isobutylhydratropic acid Advil IBUPROFEN Ibuprofen Motrin ibuprofen |
|
Definitions |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C561 |
|
ALT_DEFINITION |
A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID). |
|
CAS_Registry |
15687-27-1 |
|
CHEBI_ID |
CHEBI:5855 |
|
Chemical_Formula |
C13H18O2 |
|
code |
C561 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05) |
|
Display_Name |
Ibuprofen |
|
FDA_UNII_Code |
WK2XYI10QM |
|
FULL_SYN |
Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)- p-Isobutylhydratropic acid p-Isobutylhydratropic Acid (.+ -.)-p-Isobutylhydratropic acid Advil IBUPROFEN Ibuprofen Motrin ibuprofen |
|
Has_Target | ||
label |
Ibuprofen |
|
Legacy Concept Name |
Ibuprofen |
|
NCI_Drug_Dictionary_ID |
40475 |
|
NSC Number |
256857 |
|
PDQ_Closed_Trial_Search_ID |
40475 |
|
PDQ_Open_Trial_Search_ID |
40475 |
|
Preferred_Name |
Ibuprofen |
|
prefixIRI |
Thesaurus:C561 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0593507 |
|
subClassOf |