National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Ibuprofen

Synonyms

IBUPROFEN

(.+ -.)-p-Isobutylhydratropic acid

Ibuprofen

Motrin

Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-

p-Isobutylhydratropic acid

p-Isobutylhydratropic Acid

ibuprofen

Advil

Definitions

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C561

ALT_DEFINITION

A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).

CAS_Registry

15687-27-1

CHEBI_ID

CHEBI:5855

Chemical_Formula

C13H18O2

code

C561

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

Display_Name

Ibuprofen

FDA_UNII_Code

WK2XYI10QM

FULL_SYN

IBUPROFEN

(.+ -.)-p-Isobutylhydratropic acid

Ibuprofen

Motrin

Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-

p-Isobutylhydratropic acid

p-Isobutylhydratropic Acid

ibuprofen

Advil

label

Ibuprofen

Legacy_Concept_Name

Ibuprofen

NSC_Code

256857

PDQ_Closed_Trial_Search_ID

40475

PDQ_Open_Trial_Search_ID

40475

Preferred_Name

Ibuprofen

prefixIRI

ncit:C561

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0593507

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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http://purl.jp/bio/4/id/200906004759097752 IOBC LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Ibuprofen PCALION LOOM
http://purl.jp/bio/4/id/200906005183226949 IOBC LOOM
http://www.drugbank.ca/drugs/DB01050 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007052 RH-MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Ibuprofen ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146197 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907012240750528 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387207008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/M01AE01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/C01EB16 ATC LOOM
http://purl.bioontology.org/ontology/CSP/2270-2077 CRISP LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5855 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNMI/C-603C0 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004262 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/M02AA13 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4017840 VANDF LOOM
http://stirdf.jst.go.jp/id/200907069737148009 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002377 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Ibuprofen GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6519 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP16165-0 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040475 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LA14347-1 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D007052 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020740 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/R02AX02 ATC LOOM
http://www.projecthalo.com/aura#Ibuprofen AURA LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0000606 SCDO LOOM
http://purl.bioontology.org/ontology/UATC/G02CC01 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/5640 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.701.430 RH-MESH LOOM