Preferred Name |
Floxuridine |
|
Synonyms |
2-Deoxy-5-fluorouridine 2'-Deoxy-5-fluorouridine FLOXURIDINE Fluorouridine Deoxyribose 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil floxuridine Fluorodeoxyuridine 5-Fluorouracil Deoxyriboside Floxuridine Fluoruridine Deoxyribose 5-Fluorouridine Deoxyribose Fluoruridine deoxyribose 5-Fluorodeoxyuridine 5-Fluorouracil deoxyriboside 5-Fluoro-2'-deoxy-beta-uridine 5-Fluoro-2'-deoxyuridine 5-FUDR 5-FUdR FDUR FUDR FUdR Floxuridin WR-138720 |
|
Definitions |
A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C504 |
|
Accepted_Therapeutic_Use_For |
Gastrointestinal adenocarcinoma metastatic to the liver |
|
ALT_DEFINITION |
A drug used in the treatment of cancer. It is a type of antimetabolite. |
|
CAS_Registry |
50-91-9 |
|
CHEBI_ID |
CHEBI:60761 |
|
Chemical_Formula |
C9H11FN2O5 |
|
code |
C504 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
CTRP FDA GDC HemOnc |
|
DEFINITION |
A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04) |
|
Display_Name |
Floxuridine |
|
FDA_UNII_Code |
039LU44I5M |
|
FULL_SYN |
2-Deoxy-5-fluorouridine 2'-Deoxy-5-fluorouridine FLOXURIDINE Fluorouridine Deoxyribose 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil floxuridine Fluorodeoxyuridine 5-Fluorouracil Deoxyriboside Floxuridine Fluoruridine Deoxyribose 5-Fluorouridine Deoxyribose Fluoruridine deoxyribose 5-Fluorodeoxyuridine 5-Fluorouracil deoxyriboside 5-Fluoro-2'-deoxy-beta-uridine 5-Fluoro-2'-deoxyuridine 5-FUDR 5-FUdR FDUR FUDR FUdR Floxuridin WR-138720 |
|
Has_Target | ||
Is_Value_For_GDC_Property | ||
label |
Floxuridine |
|
Legacy Concept Name |
Floxuridine |
|
Maps_To |
Floxuridine |
|
NCI_Drug_Dictionary_ID |
39242 |
|
NSC Number |
27640 |
|
PDQ_Closed_Trial_Search_ID |
39242 |
|
PDQ_Open_Trial_Search_ID |
39242 |
|
Preferred_Name |
Floxuridine |
|
prefixIRI |
Thesaurus:C504 |
|
Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
UMLS_CUI |
C0016343 |
|
subClassOf |