National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Floxuridine

Synonyms

2-Deoxy-5-fluorouridine

2'-Deoxy-5-fluorouridine

FLOXURIDINE

Fluorouridine Deoxyribose

1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

floxuridine

Fluorodeoxyuridine

5-Fluorouracil Deoxyriboside

Floxuridine

Fluoruridine Deoxyribose

5-Fluorouridine Deoxyribose

Fluoruridine deoxyribose

5-Fluorodeoxyuridine

5-Fluorouracil deoxyriboside

5-Fluoro-2'-deoxy-beta-uridine

5-Fluoro-2'-deoxyuridine

5-FUDR

5-FUdR

FDUR

FUDR

FUdR

Floxuridin

WR-138720

Definitions

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C504

Accepted_Therapeutic_Use_For

Gastrointestinal adenocarcinoma metastatic to the liver

ALT_DEFINITION

A drug used in the treatment of cancer. It is a type of antimetabolite.

CAS_Registry

50-91-9

CHEBI_ID

CHEBI:60761

Chemical_Formula

C9H11FN2O5

code

C504

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)

Display_Name

Floxuridine

FDA_UNII_Code

039LU44I5M

FULL_SYN

2-Deoxy-5-fluorouridine

2'-Deoxy-5-fluorouridine

FLOXURIDINE

Fluorouridine Deoxyribose

1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

floxuridine

Fluorodeoxyuridine

5-Fluorouracil Deoxyriboside

Floxuridine

Fluoruridine Deoxyribose

5-Fluorouridine Deoxyribose

Fluoruridine deoxyribose

5-Fluorodeoxyuridine

5-Fluorouracil deoxyriboside

5-Fluoro-2'-deoxy-beta-uridine

5-Fluoro-2'-deoxyuridine

5-FUDR

5-FUdR

FDUR

FUDR

FUdR

Floxuridin

WR-138720

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17199

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Floxuridine

Legacy Concept Name

Floxuridine

Maps_To

Floxuridine

NCI_Drug_Dictionary_ID

39242

NSC Number

27640

PDQ_Closed_Trial_Search_ID

39242

PDQ_Open_Trial_Search_ID

39242

Preferred_Name

Floxuridine

prefixIRI

Thesaurus:C504

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0016343

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1557

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http://purl.obolibrary.org/obo/CHEBI_60761 OBA LOOM
http://purl.obolibrary.org/obo/XCO_0000876 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 FYPO LOOM
https://go.drugbank.com/drugs/DB00322 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D005467 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002648 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039242 PDQ LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146171 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5125 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/1375-2970 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.430.432 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018403 PMAPP-PMO LOOM
http://www.drugbank.ca/drugs/DB00322 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_60761 GO-PLUS LOOM
http://purl.bioontology.org/ontology/VANDF/4017811 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005467 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-780E0 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0006676 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/4488 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.852.300.350 RH-MESH LOOM
http://id.nlm.nih.gov/mesh/D005467 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D005467 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387432008 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C504 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.852.300.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01BC09 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0016343 OCHV LOOM