loading...| Preferred Name |
Fentanyl |
|
| Synonyms |
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide Abstral Duragesic FENTANYL Fentanyl |
|
| Definitions |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C494 |
|
| CAS_Registry |
437-38-7 |
|
| CHEBI_ID |
CHEBI:119915 |
|
| Chemical_Formula |
C22H28N2O |
|
| code |
C494 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability. |
|
| Display_Name |
Fentanyl |
|
| FDA_UNII_Code |
UF599785JZ |
|
| FULL_SYN |
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide Abstral Duragesic FENTANYL Fentanyl |
|
| Has_Salt_Form | ||
| label |
Fentanyl |
|
| Legacy Concept Name |
Fentanyl |
|
| Preferred_Name |
Fentanyl |
|
| prefixIRI |
Thesaurus:C494 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0591423 |
|
| subClassOf |